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SARS-CoV-2 viral dynamics in infections with variants of concern in the French community

Abstract : We analysed 871,604 PCR tests performed in the community in the Paris area (France) from 1st January 2021 to 24th March 2021. The PCR cycle threshold (Ct) at symptom onset was −1.33 (95% CI [-1.59,-1.07]) and −1.15 (95% CI [-1.57,-0.697]) lower for individuals infected with B.1.1.7 and B.1.351 compared to other strains. The mean duration of infectiousness after symptom onset (time to Ct > 31) was 8.6, 9.3, 8.9 days for individuals infected with historical strains, variants B.1.1.7 and B.1.351. This study clarifies the postsymptom intra-host dynamics of B.1.1.7 and B.1.351 and suggests that higher peak viral load for these variants may explain part of their evolutionary advantage and the greater pathogenicity of B.1.1.7.
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https://hal.sorbonne-universite.fr/hal-03217231
Contributeur : François Blanquart <>
Soumis le : mardi 4 mai 2021 - 16:51:55
Dernière modification le : mercredi 2 juin 2021 - 16:26:13

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  • HAL Id : hal-03217231, version 1

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Gina Cosentino, Mathieu Bernard, Joëvin Ambroise, Jean-Marc Giannoli, Jérémie Guedj, et al.. SARS-CoV-2 viral dynamics in infections with variants of concern in the French community. 2021. ⟨hal-03217231⟩

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