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Elevated plasma Galectin-3 is associated with major adverse kidney events and death after ICU admission

Abstract : Background: Galectin-3 (Gal-3) is a proinflammatory and profibrotic protein especially overexpressed after Acute Kidney Injury (AKI). The early renal prognostic value of Gal-3 after AKI in critically ill patients remains unexplored. The objective was to evaluate the prognostic value of plasma level of Gal-3 for Major Adverse Kidney Events (MAKE) and mortality 30 days after ICU admission across AKI stages. Methods: This is an ancillary study of a prospective, observational, multicenter cohort (FROG-ICU). AKI was defined using KDIGO definition. Results: Two thousand and seventy-six patients had a Gal-3 plasma level measurement at ICU admission. Seven hundred and twenty-three (34.8%) were females and the median age was 63 [51, 74] years. Eight hundred and seven (38.9%) patients developed MAKE, 774 (37.3%) had AKI and mortality rate at 30 days was 22.4% (N = 465). Patients who developed MAKE had higher Gal-3 level at admission compared to patients without (30.2 [20.8, 49.2] ng/ml versus 16.9 [12.7, 24.3] ng/ml, p < 0.001, respectively. The area under the receiver operating characteristic curve of Gal-3 to predict MAKE was 0.76 CI 95% [0.74-0.78], p < 0.001. Gal-3 was associated with MAKE (OR 1.80 CI 95% [1.68-1.93], p < 0.001, non-adjusted and OR 1.37 CI 95% [1.27-1.49], p < 0.001, adjusted). The use of Gal-3 improved prediction performance of prediction model including SAPSII, Screat adm , pNGAL with a NRI of 0.27 CI 95% (0.16-0.38), p < 0.001. Median Gal-3 was higher in non-survivors than in survivors at 30 days (29.2 [20.2, 49.2] ng/ml versus 18.8 [13.3, 29.2] ng/ml, p < 0.001, respectively). Conclusion: Plasma levels of Gal-3 were strongly associated with renal function, with an increased risk of MAKE and death after ICU admission.
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https://hal.sorbonne-universite.fr/hal-03518948
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Soumis le : lundi 10 janvier 2022 - 11:35:30
Dernière modification le : jeudi 7 avril 2022 - 13:58:33
Archivage à long terme le : : lundi 11 avril 2022 - 21:22:19

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s13054-021-03878-x.pdf
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L. Boutin, M. Legrand, M. Sadoune, A. Mebazaa, E. Gayat, et al.. Elevated plasma Galectin-3 is associated with major adverse kidney events and death after ICU admission. Critical Care, BioMed Central, 2022, 26 (1), pp.13. ⟨10.1186/s13054-021-03878-x⟩. ⟨hal-03518948⟩

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