Proof of concept of plasmonic thermal destruction of surface cancers by gold nanoparticles obtained by green chemistry

Maroua Ben Haddada , Dimitri Koshel (1) , Zhang Yang (2) , Weiling Fu , Jolanda Spadavecchia (3) , Sabrina Pesnel (4) , Anne-Laure Morel (5)

1 CYROI - Cyclotron Réunion Océan Indien
2 Institute of Applied Physics and Computational Mathematics - IACM (Beijing, China))
3 CSPBAT - Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques
4 CIPA - Centre d'Imagerie du Petit Animal
5 CNAB - Chimie Nucléaire Analytique et Bio-environnementale

A greener approach for the design of surface plasmon resonant gold nanoparticles has been obtained with a hydrosoluble fraction of an endemic asteraceae medicinal plant. This medicinal plant is originated from Indian Ocean and demonstrates its bioreducing activity in the design of stable green nanomedicine in aqueous media. This article describes the preclinical assessment of the efficacy of these novel nanocandidates on murine model by intratumoral and intravenous injections. It definitely demonstrates two key points in the treatment of cancer: 1) optimization of the tumor microenvironment targeting by specific 2 ligands for a limited damage on healthy tissue, 2) the need to screen the specific irradiation dose (time, power) taking into account the type of tumor.

Mots clés: green nanomedicine; gold nanoparticle; medicinal plant; plasmonic photothermal therapy; hyperthermia

Domaines: Chimie

Maroua Ben Haddada, Dimitri Koshel, Zhang Yang, Weiling Fu, Jolanda Spadavecchia, et al.. Proof of concept of plasmonic thermal destruction of surface cancers by gold nanoparticles obtained by green chemistry. Colloids and Surfaces B: Biointerfaces, 2019, 184, pp.110496. ⟨10.1016/j.colsurfb.2019.110496⟩. ⟨hal-02357083⟩