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Article Dans Une Revue Cell Death and Disease Année : 2016

Genetic profiling of CLL: a ‘TP53 addict’ perspective

Résumé

Chronic lymphocytic leukaemia (CLL) is a B-cell malignancy with a highly variable clinical course. Whereas some patients require treatment relatively soon after diagnosis, others may stay free of symptoms for many years with a standard ‘watch and wait’ surveillance approach. Genomic analysis of asymptomatic patients and patients with progressive or relapsed refractory disease makes CLL an excellent model to study the course of genetic modifications in relation to the pathobiology of this disease.

Domaines

Hématologie
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Dates et versions

hal-01332729 , version 1 (16-10-2019)

Identifiants

Citer

L Lodé, F Cymbalista, Thierry Soussi. Genetic profiling of CLL: a ‘TP53 addict’ perspective. Cell Death and Disease, 2016, 7 (1), pp.e2042. ⟨10.1038/cddis.2015.415⟩. ⟨hal-01332729⟩
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